Microdosing Psilocybin2020-10-05T22:57:29+00:00


Spirit Molecule - Psilocybin Molecule

[3-(2-Dimethylaminoethyl)-1H-indol-4-yl] dihydrogen phosphate – C12H17N2O4P

Welcome to the Spirit Molecule Psilocybin Microdosing Guide. Here you will learn everything you need to know to begin microdosing with magic mushrooms today. You will find full instructions here on how the microdosing process itself takes place, we highly advise you to read the Microdosing Overview to get a good idea of what microdosing is exactly before beginning the regimen.

Pleaste note: Psilocybin containing mushrooms are illegal in some countries, we do not support or condone illegal activities in countries where the law does not prohibit. This guide is for those who live in countries where Psilocybin mushrooms are legal, as well as for those who wish to carry out the operation regardless, with the intention of providing educated advice in order to reduce the risk of harm.

“The basic concept of microdosing is nothing new. Albert Hofmann, who first synthesized LSD in 1938, considered it one of the drug’s most promising, and least researched, applications. He was among the first to realize its antidepressant and cognition-enhancing potential,[vi] famously taking between 10 and 20 μg himself, twice a week, for the last few decades of his life.”

Spirit Molecule - Magic Mushrooms


Microdosing is the act of consuming sub-perceptual amounts of a psychedelic compound such as Psilocybin or LSD. Many reports obtained from users who have taken part in microdosing studies suggest that microdosing with these substances can increase levels of energy, creativity, focus and improve rational, as well as logical skills drastically. Other reports also show that microdosing has the potential to heighten spiritual awareness and enhance one’s senses.

Scientific research on microdosing in recent times has also shown the positive effects it can have on anxiety and other mood disorders, such as PTSD and depression. In fact, The Beckley Foundation is spearheading the push for the legalization of psilocybin mushrooms, backed by long-term positive effects found in their research conducted on treatment-resistant depression patients.

Other research carried out by researchers at Johns Hopkins reported showed an 80% sobriety rate among long-term smokers who took part in a psilocybin study.

Aside from psychological issues, mushrooms (and LSD) have been found to be  “comparable to or more efficacious than most conventional medications” in treating cluster headaches. Many people have experienced extended periods of remission after taking them.

Many of these benefits are seen with higher doses of psilocybin, however, recent research has shown that microdosing at smaller doses also has life-changing benefits in all the same areas of research. With all that said, let’s get started on your journey to microdosing with psilocybin mushrooms. Make sure you have read the Microdosing Overview page fully before continuing with the guide below.


Pleaste note: Psilocybin containing mushrooms are illegal in some countries, we do not support or condone illegal activities in countries where the law does not prohibit. This guide is for those who live in countries where Psilocybin mushrooms are legal, as well as for those who wish to carry out the operation regardless, with the intention of providing educated advice in order to reduce the risk of harm.


Before you begin your journey with microdosing, it is important that you learn the laws in your country surrounding psilocybin-containing mushrooms. The laws vary depending on the country and it is your responsibility to check the laws in your country before you begin. The link below will provide you with an up to date list of countries and their laws concerning psilocybin-containing mushrooms.



In this first step, you will decide on your protocol of choice. Your protocol will outline how often you microdose and what you do in between doses. The most common microdosing protocol is the Fadiman Protocol laid out by Dr James Fadiman. This protocol was produced based on microdosing research he has been working on since 2012.

The Fadiman Protocol is great a great place to start, especially for beginners. Once you have experimented with microdosing for a few weeks you can begin to adjust the protocol to suit you and your needs. Everyone is different in how they handle the microdosing process, therefore its important for you to be present and observe yourself during this process. Only you know what works for you, we suggest you begin with the Fadiman Protocol and adjust as you see fit once you get the hang of things.

This protocol can be used for microdosing both Psilocybin and LSD and includes the following steps

Spirit Molecule Microdosing Guide - 4 Steps to Microdosing with Psilocybin & LSD


A microdose needs to be sub-perceptual, that means the dose should be roughly 1/10th of a standard dose, this can vary from person to person but it is typically in that range and only differs by a small amount. Typically, a standard dose of psilocybin mushrooms is approximately 3.5 grams of dried mushrooms. A microdose therefore, is around 0.2 to 0.3 grams.


You should make it a habit to journal throughout the day when you begin microdosing. Take notes on any changes you see in your mood, perception, mental state, or feelings that arise on your microdosing day and the day after.


You should calibrate your dose slowly to adjust to your needs. Everyone’s dose will be different and there are many factors that influence this, including body composition, mental state, and prior experience with psychedelics. When calibrating, make incremental changes in the amount you take. This will help to optimize the experience.


By following the Fadiman Protocol you will be dosing on day 1, resting for 2 days and then dosing again on 4 and so on. So for example, if your first dose was on Monday, you don’t dose again until Thursday. We recommend you microdose for 8 weeks and taking a break to evaluate the outcome. You should take intermittent breaks from microdosing in order to allow your body to adjust and not build a tolerance.


In order to microdose with psilocybin mushrooms, you’re going to need psilocybin mushrooms! The problem is, the society in which we live in has deemed it logical to outlaw its use. It is legal in some countries but still widely prohibited. The best way to get your hands on mushrooms you can trust is to grow your own. We have put together a comprehensive guide on how to grow your own mushrooms and sell a wide variety of Grow Kits in our store for the absolute beginner. Growing your own mushrooms will provide you with an unlimited supply of mushrooms. We recommend signing up for our upcoming Cultivation Video Course that will teach you everything you need to go from novice to advance in no time. You can pre-register using the form below now and receive a 15% discount on launch day.

If you live in Europe, you may have the option of purchasing psilocybin truffles, which are legal in the Netherlands. Remember, these are less potent than psilocybin mushrooms, and an ideal starter dose is 0.5g of dried truffle powder.

Any type of psilocybin mushroom strain will work for microdosing. The most popular strains used are Psilocybe Cubensis, Psilocybe Semilanceata and Psilocybe Cyanescens. One important note to remember is that each type of strain will contain different amounts of the active compound, psilocybin. You will need to adjust your dose according to the strength of your strain, for the sake of this guide, everything is based on the average strength of the Psilocybe Cubensis strain. We have provided a table below to help you learn more about the potency levels of different Psilocybe strains.

Other options for sourcing mushrooms include searching on the dark web or finding a local supplier. Whichever option you choose, remember, be wise, be safe.



    When microdosing with Psilocybin you don’t want to cause a substantial change in your mood, disposition, or mindset. You want to achieve effects that are subtle and stealth.

    Preparing your psilocybin microdoses is not complicated, the most important thing is to ensure your mushrooms are completely dry. Fresh and dried magic mushrooms contain different amounts of the active ingredient, psilocybin, mushrooms are almost 80% water, so once dried the weight differs quite a lot and you will want to calculate all of your microdoses based on dried mushrooms. Different strains of mushrooms will also have different psilocybin contents and it is wise to familiarise yourself with the strain you are using, below is a table of the different strengths of different mushroom strains.


    Please note that these do not represent average values for widely sampled populations. Just because a mushroom species has some samples that show high or low concentrations does not mean that all mushrooms of that type have levels matching those in this chart.

    P. azurenscens 1.78 .38 .35
    P. bohemica 1.34 .11 .02
    P. semilanceata .98 .02 .36
    P. baeocystis .85 .59 .10
    P. cyanescens .85 .36 .03
    P. tampanensis .68 .32 n/a
    P. cubensis .63 .60 .025
    P. weilii .61 .27 .05
    P. hoogshagenii .60 .10 n/a
    P. stuntzii .36 .12 .02
    P. cyanofibrillosa .21 .04 n/a
    P. liniformans .16 n/d .005

    *Original source.

    If that wasn’t enough, the stem of the mushroom contains different amounts of psilocybin compared to the cap, so when microdosing it is important to get a consistent amount each time, evenly distributed psilocybin in every dose. The best way to achieve this is to grind your mushrooms into a powder, this ensures the content is mixed evenly and you will get a consistent dose each time that you can rely on. If you were to simply eat the mushrooms whole you would be getting a different ratio of psilocybin each time, the last thing you want is to start tripping at work!

    The best way to grind up your mushrooms is to use a coffee grinder, easy! First measure out how much mushrooms you want to use for your microdosing protocol and throw them into the grinder, once turned to powder, empty out your powdered mushrooms into a clean container. At this stage you have 2 options, you can simply measure out your dose out of this batch each time you microdose using your scales, or you can purchase Gelatine Capsules and make yourself some handy microdose pills that are discrete and easy to drop. For this you will need to purchase a capsule maker, these can be found for around £14 on eBay and are a worthwhile investment if you are taking your microdosing protocol seriously.

    Once you have prepared your powdered mushrooms you are ready to move on to the final step.

    Spirit Molecule - Magic Mushrooms


    Congratulations, you have sourced your mushrooms and prepared your doses. Hopefully you invested in a capsule maker and prepared yourself some lovely capsules so you’re ready to go every morning. If you don’t have a capsule maker, don’t worry, you will still get the full effect, you will just need to spend that extra minute each time you want to dose, but no biggie, after your first microdose you won’t care!

    Hopefully, you have reviewed the protocol too and are familiar with it. Pick the day you want to begin your microdosing protocol and start a journal, take notes on how you feel, what you want to achieve from this regimen and make a habit of doing this daily. When you are ready to begin measure out roughly 0.1g of powdered mushrooms for your first dose if you weigh up to 100 lbs, or 0.25 if you weight 200 lbs+, this will be your starting dose. This dose will allow you to slowly build-up to the dose you feel is right for you. As mentioned earlier, everyone is different and you will need to find the right dose for you.

    When microdosing, you want to reach the level just before you begin to “feel” like you’ve taken something. On your second dose, increase the dosage to 0.15g and on your 3rd dose go up to 0.2g, once you reach a level where you begin to feel high or you get a slight body high you have found your dose, you simply decrease your last dose slightly until the body high is reduced. Some microdosers actually enjoy riding at this level and it can be quite fun if you are happy to feel like you’ve taken something for a portion of the day. However, most want to microdose without feeling like they have taken a drug, so adjust your dose until you are just below this threshold and that is your sweet spot, continue at this dose for the remainder of your protocol.

    For most people, morning is the best time for microdosing because the beneficial effects will last throughout the day, microdosing at night could interfere with sleep. You should begin to notice a difference within 45 minutes of taking your microdose on an empty stomach.


    You should observe the effects of your microdose throughout your protocol by taking notes in a journal daily, even on days you are not microdosing. Continue your protocol for 8 weeks, taking notes throughout the entire process. Make specific notes on your mood, social behaviours, emotions and energy. Pay attention to any emotional issues you may be suffering from, such as depression and anxiety, make notes on what changes you notice. If you suffer from any sort of addiction, it is a good idea to pay attention to cravings and how they are affected, many microdosers report microdosing has helped them kick smoking and other types of addiction.

    Integrating microdosing into your daily routine should not change what you do on a normal day, you shouldn’t change your behaviour, routines and habits, simply incorporate the microdosing into your day and observe the effects. The point is to allow the microdose to improve your quality of life and help you make decisions to change things for the better, open up to it and let it do its magic.

    On your first day of microdosing, it might be a good idea to take the day off from work, as well as other social commitments. It will give you the chance to observe the effects without having to be in public.

    Be vigilant in observing the effects of microdosing on the two days between doses. Many people perceive increased feelings of flow, creativity, and energy the day after they microdose, as well as the day of microdosing.

    It is not recommended that you microdose every day. Psilocybin can produce tolerance, so you might see diminishing returns after a few days if you do it every day. This is why the protocol is set out the way it is, to allow the body to adjust and avoid building a tolerance. Furthermore, it is not required to microdose daily, the effects last up to 48 hours, so even after your microdose, you will continue to benefit from the positive effects.

    That’s it, you have successfully completed your psilocybin microdosing protocol. If you want to take your microdosing protocol to the next level sign up below to be one of the first to get notified when our Microdosing Course launches, you will receive 15% discount on launch day if you pre-register now.



      What different kinds of mushrooms can be used for microdosing?

      All psilocybin-containing mushrooms are ok to use. The most common strain used by many is Golden Teacher (Psilocybe cubensis) or Liberty caps (Psilocybe semilanceata). The effects of a microdose are sub-perceptual, so the strain should not produce any changes in effect. If you do notice some changes or effects you did not notice with other strains, it may be that your new batch has a higher psilocybin content, or you just took too much. Try lowering the dose slightly until you find your sweet spot again.

      What is the best way to take my psilocybin microdose?

      The best and most practical option is to take your dose in capsule form. Capsule making machines can be purchased relatively cheaply on eBay and are a worthwhile investment for all serious microdosers. Doing it this way ensures you get an accurate and consistent dose every time.

      Otherwise, you can use a small teaspoon to measure out the powder and either just down it or mix it in with your tea, coffee, cereal, smoothie or any other food you like.

      How can I grind my mushroom in to a powder?

      The best option would be to use a small coffee grinder, which can be purchased relatively cheaply on eBay. This is the quickest and most accurate way of powdering your dry mushrooms. Alternatively, you can use a weed hand grinder, or a pair of scissors to finely chop the mushrooms, although this will not be as accurate as powdering the mushrooms in a grinder.

      What if I take too little?

      If you don’t take the right microdose and are below the microdose range (0.1g – 0.4g) then you won’t notice any changes, either top up your dose to match your protocol dose, or skip it and take the correct dose next time.

      What if I take too much?

      If you take too much psilocybin but are still within the microdose range (0.1g to 0.4g), you may notice some effects, such as mental hyperactivity, body tingling, sweating and a loss of appetite. The effects will not be severe and you will still be able to go on with your day but you will be aware of the microdose. Don’t worry, you are still within the microdose range here. The key is to find the dosage right before you begin to notice effects, lower your dose slightly next time.

      If you take too much psilocybin and are outside of the microdose range (0.5g+), depending on the strain, you may start tripping balls! How you manage the rest of your day from here will depend on how much you took. The most important thing is to stay calm and not panic, it’s done now, just enjoy the ride!

      Is it safe to microdose psilocybin mushrooms?

      The riskiest thing about microdosing is its possibly illegal nature, depending on where you live. Always be aware of the laws in your country.

      The first-ever controlled, double-blind study of microdosing LSD and Psilocybin suggests that the practice is more effective than a placebo and that it is safe. However, there hasn’t been any long term research done on frequent microdosing over an extended period of time, therefore we cannot comment on how safe it is and would recommend you to microdose for no longer than 8 weeks at a time. Having said that, there has been enough research over the decades to prove psilocybin mushrooms are completely safe to consume in reasonable and safe doses.

      The best thing about microdosing is that there is no risk of having a “bad trip” or experiencing intense psychedelic effects.

      Can a psilocybin microdose be detected in a drug test?

      Psilocybin and its metabolites are not included in most standard drug screens. However, they are sometimes included in extended drug screens and can show up.

      Where can I get psilocybin mushrooms?

      Either grow your own using a Grow Kit or read our guide on how to Cultivate your own mushrooms at home.

      Is microdosing legal?

      Microdosing is not necessarily illegal. Several countries allow the cultivation of psilocybin mushrooms, the purchase of psilocybin truffles, or the purchase of LSD analogues. We do not condone microdosing where it is against the law, as penalties can be severe. It is your responsibility to check the laws in your country.

      Where can I get microdosing supplies or items needed to grow my own mushrooms?

      We sell a wide variety of supplies in or Spirit Store to help you both with your microdosing and mushroom cultivation projects.


      Read the latest articles about Microdosing on our blog. If you are interested in contributing to our blog please contact us, we are always looking to expand our circle and welcome offers of partnership.


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